LC-MS Introduction

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LC-MS Introduction

LC-MS is a hyphenated technique, which combines the separating power of high performance liquid chromatography (HPLC), with the detection power of mass spectrometry (MS). LC-MS covers a broad range of application areas. This module explores the instrument acquisition methods used and examines the type of data that can be produced from such systems.

Topics include:

Definitions
Instrument fundamentals
LC-MS process
Why and when to use LC-MS
Ionization overview
Atmospheric pressure ionization (API)
Electrospray ionization (ESI)
Atomospheric pressure chemical ionization (APCI)
Atomospheric pressure photoionization (APPI)
Mass analyzers
Quadrupole mass analyzer
Time-of-flight mass analyzer
Ion trap mass analyzer
Tandem mass spectrometry (MS/MS)
Detectors

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