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We have previously considered the first stages of solid phase extraction (SPE) method development, that is, analyte assessment and mechanism selection. Once a primary extraction mechanism has been selected, e.g. polar, non-polar, ion exchange etc., several sorbents which exhibit the chosen mechanism should be screened – this screening process provides the flexibility of having multiple effective sorbent choices to ensure the cleanest extracts for the final protocol.

SPE Sorbent Screening